PF3D7_1449100

Genome location: Pf3D7_14_v3:2,007,923..2,013,037(+)

Genome classification: Core

Function and Localization

Product Description: CLASP domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005881	cytoplasmic microtubule
Component	GO:0005634	nucleus
Function	GO:0008017	microtubule binding
Process	GO:0000226	microtubule cytoskeleton organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	possibly expressed	0.32	0.80
Schizont	expressed	0.99	0.49
Gametocyte	not expressed	0.78	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1449100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -2.88 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1312800)

Relative Growth Rate: 0.93 ± 0.22
Confidence: 4.46

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1312800)

Modification: Disrupted | RMgm-3468

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKY3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111884

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	52	31	82
disruptive	41	201	119	252
missense	33	167	106	211

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	121	50	73
disruptive	86	424	179	364
missense	69	345	145	246

PlasmoDB Total SNPs: 298

Non-coding: 202 | Synonymous: 43 | Nonsynonymous: 52 | Stop Codon: 1

Protein Information

Protein Length: 1029 | Molecular Weight (kDa): 121.111

UniProt ID(s): Q8IKY3

PDB ID(s): None

Isoelectric Point: 8.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR024395	CLASP N-terminal domain
PFam	PF12348	CLASP N-terminal domain
Superfamily	SSF48371	Armadillo-type fold

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108