PF3D7_1449200

Genome location: Pf3D7_14_v3:2,013,486..2,015,102(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.15	0.93
Trophozoite	no data	0.31	0.83
Schizont	no data	3.11	0.11
Gametocyte	no data	0.18	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1449200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.807 | MFS: -3.535 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3J1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6r19_457519

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	5	1	6
disruptive	1	10	1	15
missense	1	8	1	9

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	11	2	9
disruptive	5	23	18	26
missense	1	16	13	14

PlasmoDB Total SNPs: 126

Non-coding: 116 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 85 | Molecular Weight (kDa): 9.538

UniProt ID(s): C6S3J1

PDB ID(s): None

Isoelectric Point: 11.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A