About Gene List

PF3D7_1449600

Genome location: Pf3D7_14_v3:2,034,617..2,036,674(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite not expressed 0.03 0.98
Schizont expressed 0.28 0.81
Gametocyte possibly expressed 0.10 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1449600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.135 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1313300)

Modification: Tagged | RMgm-4948

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKX9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158751

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 19 17 39
disruptive 16 68 36 77
missense 15 61 35 68

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 48 19 46
disruptive 32 141 66 159
missense 26 117 61 98

PlasmoDB Total SNPs: 69

Non-coding: 35 | Synonymous: 17 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 504 | Molecular Weight (kDa): 60.626

UniProt ID(s): Q8IKX9

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
33705380 Molecular characterization of the conoid complex in Toxoplasma reveals itsconservation in all apicomplexans, including Plasmodium species. Koreny L, Zeeshan M, ..., Waller RF 10.1371/journal.pbio.3001081