PF3D7_1449800

Genome location: Pf3D7_14_v3:2,042,131..2,043,795(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.06	0.97
Trophozoite	expressed	0.07	0.95
Schizont	possibly expressed	0.02	0.99
Gametocyte	expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1449800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.201 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1313500)

Relative Growth Rate: 0.16 ± 0.14
Confidence: 5.38

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKX7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_118076

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	3	13
disruptive	3	25	13	22
missense	3	25	13	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	20	11	19
disruptive	7	47	25	61
missense	7	43	19	45

PlasmoDB Total SNPs: 70

Non-coding: 58 | Synonymous: 4 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 177 | Molecular Weight (kDa): 20.658

UniProt ID(s): Q8IKX7

PDB ID(s): None

Isoelectric Point: 4.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104