Genome location: Pf3D7_14_v3:2,051,429..2,053,788(-)
Genome classification: Core
Product Description: signal recognition particle subunit SRP54
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting |
| Function | GO:0008312 | 7S RNA binding |
| Function | GO:0030942 | endoplasmic reticulum signal peptide binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0043022 | ribosome binding |
| Function | GO:0005048 | signal sequence binding |
| Process | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
| Process | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.33 | 0.83 |
| Trophozoite | expressed | 0.19 | 0.88 |
| Schizont | expressed | 0.21 | 0.85 |
| Gametocyte | expressed | 0.20 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1450100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.044 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKX4
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.01) with 5L3Q (Global RMSD=1.68)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100507
Most Similar Human Ortholog: A0A7I2V584
TM-align score: 0.90 | RMSD: 2.18
Seq Identity: 0.55 | Length: 323 / 500
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100883 | signal recognition particle 54 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 26 | 17 | 32 |
| disruptive | 0 | 14 | 12 | 41 |
| missense | 0 | 14 | 8 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 59 | 15 | 29 |
| disruptive | 4 | 62 | 36 | 133 |
| missense | 2 | 51 | 28 | 85 |
PlasmoDB Total SNPs: 171
Non-coding: 157 | Synonymous: 10 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 500 | Molecular Weight (kDa): 55.979
PDB ID(s): None
Isoelectric Point: 9.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000897 | Signal recognition particle, SRP54 subunit, GTPase domain |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR004125 | Signal recognition particle, SRP54 subunit, M-domain |
| InterPro | IPR006325 | Signal recognition particle, SRP54 subunit, eukaryotic |
| InterPro | IPR013822 | Signal recognition particle SRP54, helical bundle |
| InterPro | IPR022941 | Signal recognition particle, SRP54 subunit |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036225 | SRP/SRP receptor, N-terminal |
| InterPro | IPR036891 | Signal recognition particle, SRP54 subunit, M-domain superfamily |
| PFam | PF00448 | Signal recognition particle, SRP54 subunit, GTPase domain |
| PFam | PF02881 | Signal recognition particle SRP54, helical bundle |
| PFam | PF02978 | Signal recognition particle, SRP54 subunit, M-domain |
| Superfamily | SSF47364 | SRP/SRP receptor, N-terminal |
| Superfamily | SSF47446 | Signal recognition particle, SRP54 subunit, M-domain superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17919451 | Unraveling the components of protein translocation pathway in human malariaparasite Plasmodium falciparum. | Tuteja R | 10.1016/j.abb.2007.08.031 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24434517 | Plasmodium falciparum signal recognition particle components and anti-parasiticeffect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP. | Panchal M, Rawat K, ..., Tuteja R | 10.1038/cddis.2013.521 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 36273743 | SRP54 mediates circadian rhythm-related, temperature-dependent gene expression inDrosophila | Li Y, Yang X, Zhao Z, Du J | 10.1016/j.ygeno.2022.110512 |