PF3D7_1450200

Genome location: Pf3D7_14_v3:2,055,238..2,056,437(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.20	0.90
Trophozoite	no data	0.25	0.84
Schizont	no data	0.09	0.94
Gametocyte	no data	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1450200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.204 | MFS: -3.912 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3J2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532637

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	5	2	8
disruptive	3	9	8	21
missense	3	9	8	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	8	6	12
disruptive	7	23	14	47
missense	7	18	12	31

PlasmoDB Total SNPs: 76

Non-coding: 71 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 126 | Molecular Weight (kDa): 14.922

UniProt ID(s): C6S3J2

PDB ID(s): None

Isoelectric Point: 9.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A