PF3D7_1450500

Genome location: Pf3D7_14_v3:2,067,739..2,073,656(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.32	0.81
Schizont	possibly expressed	0.89	0.52
Gametocyte	not expressed	0.37	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1450500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.077 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1314200)

Relative Growth Rate: 0.92 ± 0.07
Confidence: 6.78

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1314200)

Modification: Disrupted | RMgm-3472

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKX1

"Best" AlphaFill ligand hit: NDP (nadph dihydro-nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.29) with 8JFB (Global RMSD=19.85)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532963

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	28	92	48	117
disruptive	135	395	181	413
missense	73	269	148	318

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	40	166	77	135
disruptive	214	700	279	531
missense	114	499	225	352

PlasmoDB Total SNPs: 356

Non-coding: 99 | Synonymous: 114 | Nonsynonymous: 143 | Stop Codon: 0

Protein Information

Protein Length: 1653 | Molecular Weight (kDa): 199.739

UniProt ID(s): Q8IKX1

PDB ID(s): None

Isoelectric Point: 4.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094