About Gene List

PF3D7_1450800

Genome location: Pf3D7_14_v3:2,080,781..2,082,574(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.02 0.99
Trophozoite expressed 0.11 0.92
Schizont possibly expressed 0.03 0.98
Gametocyte possibly expressed 0.08 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1450800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.965 | MFS: -2.854 | #Insertions: 2

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1314500)

  • Relative Growth Rate: 0.07 ± 0.05
  • Confidence: 7.37

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKW8

"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=4.99) with 4YT3 (Global RMSD=17.94)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215381

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 28 13 35
disruptive 10 47 39 73
missense 9 46 39 71

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 59 17 31
disruptive 20 103 51 106
missense 16 96 49 99

PlasmoDB Total SNPs: 100

Non-coding: 51 | Synonymous: 27 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 449 | Molecular Weight (kDa): 53.393

UniProt ID(s): Q8IKW8

PDB ID(s): None

Isoelectric Point: 9.43

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21