Product Description: acetyl-CoA acetyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.1.9 (Acetyl-CoA C-acetyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003985 | acetyl-CoA C-acetyltransferase activity |
| Function | GO:0003988 | acetyl-CoA C-acyltransferase activity |
| Process | GO:0006635 | fatty acid beta-oxidation |
| Process | GO:0006631 | fatty acid metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.16 | 0.90 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1450900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.162 | MFS: -2.727 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1314600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKW7
"Best" AlphaFill ligand hit: ACO (acetyl coenzyme *a, Local RMSD=0.02) with 1WDK (Global RMSD=2.78)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.9 | acetyl-CoA C-acetyltransferase | ATPCoANADHNADPHacetyl-CoAiodoacetatebutyryl-CoAiodoacetamidethiolactomycin3-butynoyl-CoA2-butynoyl-CoAacetoacetyl-CoA... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P24752 | Acetyl-CoA acetyltransferase, mitochondrial | HOGENOM, OrthoDB | CHEMBL5203276CHEMBL5204128 |
Ortholog Group (OrthoMCL): OG6_100472
Most Similar Human Ortholog: A0A5F9ZHL1
TM-align score: 0.92 | RMSD: 1.94
Seq Identity: 0.34 | Length: 384 / 398
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000075239 | acetyl-CoA acetyltransferase 1 |
| ENSG00000120437 | acetyl-CoA acetyltransferase 2 |
Protein Length: 398 | Molecular Weight (kDa): 44.373
UniProt ID(s): Q8IKW7
PDB ID(s): None
Isoelectric Point: 6.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002155 | Thiolase |
| InterPro | IPR016039 | Thiolase-like |
| InterPro | IPR020613 | Thiolase, conserved site |
| InterPro | IPR020616 | Thiolase, N-terminal |
| InterPro | IPR020617 | Thiolase, C-terminal |
| PFam | PF00108 | Thiolase, N-terminal |
| PFam | PF02803 | Thiolase, C-terminal |
| Superfamily | SSF53901 | Thiolase-like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 39 | 18 | 23 |
| disruptive | 8 | 44 | 35 | 70 |
| missense | 8 | 42 | 35 | 67 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 60 | 22 | 28 |
| disruptive | 18 | 99 | 54 | 86 |
| missense | 17 | 92 | 54 | 70 |
PlasmoDB Total SNPs: 108
Non-coding: 69 | Synonymous: 26 | Nonsynonymous: 12 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |