PF3D7_1451000

Genome location: Pf3D7_14_v3:2,084,719..2,087,663(-)

Genome classification: Core

Function and Localization

Product Description: ADP-ribosylation factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005794	Golgi apparatus
Process	GO:0043001	Golgi to plasma membrane protein transport
Process	GO:0006886	intracellular protein transport
Process	GO:0033365	protein localization to organelle

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.34	0.84
Trophozoite	expressed	0.41	0.76
Schizont	expressed	0.09	0.94
Gametocyte	expressed	0.54	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1451000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.991 | MFS: -2.641 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKW6

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.79) with 2QTH (Global RMSD=8.97)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533641

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	37	33	63
disruptive	31	162	85	211
missense	30	159	81	200

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	84	44	64
disruptive	69	336	124	197
missense	56	314	112	167

PlasmoDB Total SNPs: 129

Non-coding: 47 | Synonymous: 41 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 804 | Molecular Weight (kDa): 95.254

UniProt ID(s): Q8IKW6

PDB ID(s): None

Isoelectric Point: 6.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006689	Small GTPase superfamily, ARF/SAR type
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00025	Small GTPase superfamily, ARF/SAR type
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase