PF3D7_1451200

Genome location: Pf3D7_14_v3:2,094,050..2,102,787(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	2.95	0.13
Trophozoite	expressed	1.97	0.20
Schizont	expressed	1.37	0.37
Gametocyte	expressed	1.18	0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1451200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.046 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1314900)

Modification: Disrupted | RMgm-3477

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKW4

"Best" AlphaFill ligand hit: 1YJ (n-[4-({[(6r)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-l-glutamic acid, Local RMSD=1.77) with 5UIL (Global RMSD=18.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532377

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	84	56	145
disruptive	64	320	139	332
missense	41	301	128	293

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	181	95	130
disruptive	129	557	219	434
missense	94	493	183	311

PlasmoDB Total SNPs: 396

Non-coding: 248 | Synonymous: 55 | Nonsynonymous: 93 | Stop Codon: 0

Protein Information

Protein Length: 1504 | Molecular Weight (kDa): 176.23

UniProt ID(s): Q8IKW4

PDB ID(s): None

Isoelectric Point: 5.27

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
28288121	A genetic system to study Plasmodium falciparum protein function.	Birnbaum J, Flemming S, ..., Spielmann T	10.1038/nmeth.4223
29590075	GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependentgene silencing.	Filarsky M, Fraschka SA, ..., Voss TS	10.1126/science.aan6042