About Gene List

PF3D7_1451500

Genome location: Pf3D7_14_v3:2,113,167..2,114,460(-)

Genome classification: Core

Function and Localization

Product Description: pre-mRNA-splicing factor CWF18, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005684 U2-type spliceosomal complex
Component GO:0005634 nucleus
Component GO:0071014 post-mRNA release spliceosomal complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.20 0.90
Trophozoite possibly expressed 0.29 0.81
Schizont possibly expressed 0.05 0.97
Gametocyte not expressed 0.15 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1451500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.554 | MFS: -2.03 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1315200)

  • Relative Growth Rate: 0.09 ± 0.03
  • Confidence: 8.14

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKW1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103244

Most Similar Human Ortholog: S4R331

TM-align score: 0.35 | RMSD: 3.07

Seq Identity: 0.07 | Length: 40 / 147

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000160799 coiled-coil domain containing 12

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 1 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 1 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 92

Non-coding: 80 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 147 | Molecular Weight (kDa): 17.257

UniProt ID(s): Q8IKW1

PDB ID(s): None

Isoelectric Point: 4.74

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013169 mRNA splicing factor Cwf18-like
PFam PF08315 mRNA splicing factor Cwf18-like
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108