Genome location: Pf3D7_14_v3:2,118,608..2,121,135(-)
Genome classification: Core
Product Description: calcineurin subunit B
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005955 | calcineurin complex |
| Component | GO:0005737 | cytoplasm |
| Function | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity |
| Process | GO:0044409 | entry into host |
| Process | GO:0006470 | protein dephosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | not expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.40 | 0.75 |
| Gametocyte | possibly expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1451700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.996 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1315400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1315400)
Modification: Disrupted | RMgm-3481
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKV9
"Best" AlphaFill ligand hit: FK5 (k506, Local RMSD=0.17) with 7U0U (Global RMSD=2.55)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101614
Most Similar Human Ortholog: F6U1T9
TM-align score: 0.98 | RMSD: 0.78
Seq Identity: 0.51 | Length: 160 / 177
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000188386 | protein phosphatase 3 regulatory subunit B, beta |
| ENSG00000221823 | protein phosphatase 3 regulatory subunit B, alpha |
| ENSG00000273398 | novel protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 69
Non-coding: 68 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 177 | Molecular Weight (kDa): 20.079
PDB ID(s): None
Isoelectric Point: 4.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002048 | EF-hand domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| PFam | PF13499 | EF-hand domain |
| Superfamily | SSF47473 | EF-hand domain pair |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15230980 | Post-translational generation of constitutively active cores from largerphosphatases in the malaria parasite, Plasmodium falciparum: implications forproteomics. | Kumar R, Musiyenko A, ..., Barik S | 10.1186/1471-2199-5-6 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 26118996 | Parasite Calcineurin Regulates Host Cell Recognition and Attachment byApicomplexans. | Paul AS, Saha S, ..., Duraisingh MT | 10.1016/j.chom.2015.06.003 |