Genome location: Pf3D7_14_v3:2,123,012..2,126,797(+)
Genome classification: Core
Product Description: sortilin
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 3.2.1.18 (Exo-alpha-sialidase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0005801 | cis-Golgi network |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016021 | integral component of membrane |
| Function | GO:0005319 | lipid transporter activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0006897 | endocytosis |
| Process | GO:0006892 | post-Golgi vesicle-mediated transport |
| Process | GO:0015031 | protein transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.79 | 0.57 |
| Schizont | expressed | 0.38 | 0.77 |
| Gametocyte | expressed | 0.91 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1451800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.572 | MFS: -2.361 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKV8
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.2.1.18 | exo-alpha-sialidase | I2SDSEDTANH4+rutinHEPESNeu5AcAG7088ononinheparinchrysinvitexin... |
Orthology to BindingDB Entries:
Ortholog Group (OrthoMCL): OG6_101285
Most Similar Human Ortholog: A0A0J9YX61
TM-align score: 0.79 | RMSD: 1.79
Seq Identity: 0.20 | Length: 105 / 895
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134243 | sortilin 1 |
| ENSG00000137642 | sortilin related receptor 1 |
Protein Length: 895 | Molecular Weight (kDa): 102.27
UniProt ID(s): Q8IKV8
PDB ID(s): None
Isoelectric Point: 6.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006581 | VPS10 |
| InterPro | IPR031777 | Sortilin, C-terminal |
| InterPro | IPR031778 | Sortilin, N-terminal |
| InterPro | IPR036278 | Sialidase superfamily |
| PFam | PF15901 | Sortilin, C-terminal |
| PFam | PF15902 | Sortilin, N-terminal |
| Superfamily | SSF110296 | Sialidase superfamily |
| Superfamily | SSF50939 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 38 | 15 | 43 |
| disruptive | 4 | 21 | 9 | 43 |
| missense | 4 | 20 | 8 | 39 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 76 | 25 | 51 |
| disruptive | 7 | 52 | 31 | 127 |
| missense | 4 | 44 | 25 | 87 |
PlasmoDB Total SNPs: 92
Non-coding: 62 | Synonymous: 23 | Nonsynonymous: 7 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 24587025 | Evidence for a Golgi-to-endosome protein sorting pathway in Plasmodiumfalciparum. | Krai P, Dalal S, Klemba M | 10.1371/journal.pone.0089771 |
| 29299530 | Evidence that the Plasmodium falciparum Protein Sortilin Potentially Acts as an Escorter for the Trafficking of the Rhoptry-Associated Membrane Antigen to the Rhoptries | Hallee S, Boddey JA, Cowman AF, Richard D | 10.1128/mSphere.00551-17 |
| 29582546 | The malaria parasite Plasmodium falciparum Sortilin is essential for merozoiteformation and apical complex biogenesis. | Hallee S, Counihan NA, ..., Richard D | 10.1111/cmi.12844 |