Genome location: Pf3D7_14_v3:2,127,597..2,132,011(-)
Genome classification: Core
Product Description: ribosome biogenesis protein TSR1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030688 | preribosome, small subunit precursor |
| Function | GO:0005525 | GTP binding |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0034511 | U3 snoRNA binding |
| Process | GO:0000479 | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.50 | 0.76 |
| Trophozoite | expressed | 0.53 | 0.70 |
| Schizont | expressed | 0.31 | 0.80 |
| Gametocyte | expressed | 0.39 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1451900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.159 | MFS: -2.786 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKV7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102221
Most Similar Human Ortholog: Q2NL82
TM-align score: 0.70 | RMSD: 4.18
Seq Identity: 0.25 | Length: 624 / 1029
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000167721 | TSR1 ribosome maturation factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 45 | 28 | 72 |
| disruptive | 30 | 157 | 93 | 185 |
| missense | 15 | 133 | 82 | 161 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 81 | 42 | 72 |
| disruptive | 75 | 298 | 129 | 290 |
| missense | 42 | 243 | 109 | 220 |
PlasmoDB Total SNPs: 162
Non-coding: 73 | Synonymous: 46 | Nonsynonymous: 43 | Stop Codon: 0
Protein Length: 1029 | Molecular Weight (kDa): 120.667
UniProt ID(s): Q8IKV7
PDB ID(s): None
Isoelectric Point: 8.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007034 | Ribosome biogenesis protein BMS1/TSR1, C-terminal |
| InterPro | IPR012948 | AARP2CN |
| InterPro | IPR039761 | Ribosome biogenesis protein Bms1/Tsr1 |
| PFam | PF04950 | Ribosome biogenesis protein BMS1/TSR1, C-terminal |
| PFam | PF08142 | AARP2CN |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 36288402 | Sequences and proteins that influence mRNA processing in Trypanosoma brucei:Evolutionary conservation of SR-domain and PTB protein functions | Waithaka A, Maiakovska O, ..., Clayton C | 10.1371/journal.pntd.0010876 |
| 32138239 | Good Vibrations: Structural Remodeling of Maturing Yeast Pre-40S RibosomalParticles Followed by Cryo-Electron Microscopy | Shayan R, Rinaldi D, ..., Plisson-Chastang C | 10.3390/molecules25051125 |