PF3D7_1452100 (LRR3)

Genome location: Pf3D7_14_v3:2,141,381..2,142,754(+)

Genome classification: Core

Function and Localization

Product Description: leucine-rich repeat protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0043014	alpha-tubulin binding
Process	GO:0000226	microtubule cytoskeleton organization
Process	GO:0007023	post-chaperonin tubulin folding pathway
Process	GO:0007021	tubulin complex assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.21	0.89
Trophozoite	possibly expressed	0.13	0.92
Schizont	not expressed	0.04	0.98
Gametocyte	not expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1452100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.123 | MFS: -3.788 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKV5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107201

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	20	8	15
disruptive	2	21	17	34
missense	2	21	16	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	28	16	19
disruptive	6	49	27	45
missense	3	44	24	39

PlasmoDB Total SNPs: 44

Non-coding: 33 | Synonymous: 5 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 338 | Molecular Weight (kDa): 40.265

UniProt ID(s): Q2TFW8, Q8IKV5

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52058	N/A