Product Description: aminomethyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.2.10 (Aminomethyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005759 | mitochondrial matrix |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Process | GO:0016226 | iron-sulfur cluster assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.10 | 0.93 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | not expressed | 0.10 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1452200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -3.014 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKV4
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.1.2.10 | aminomethyltransferase | iodoacetamideN-ethylmaleimide |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102468
Most Similar Human Ortholog: Q5T440
TM-align score: 0.73 | RMSD: 3.72
Seq Identity: 0.18 | Length: 306 / 524
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000181873 | iron-sulfur cluster assembly factor IBA57 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 33 | 19 | 34 |
| disruptive | 7 | 55 | 37 | 84 |
| missense | 7 | 55 | 35 | 81 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 56 | 23 | 32 |
| disruptive | 18 | 112 | 70 | 107 |
| missense | 14 | 100 | 65 | 94 |
PlasmoDB Total SNPs: 98
Non-coding: 43 | Synonymous: 38 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 524 | Molecular Weight (kDa): 62.352
UniProt ID(s): Q8IKV4
PDB ID(s): None
Isoelectric Point: 8.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | SSF103025 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |