Genome location: Pf3D7_14_v3:2,144,927..2,146,499(-)
Genome classification: Core
Product Description: DER1-like protein
SignalP Peptide: MNFILYIAVIIIYLTNIHC
# Transmembrane Domains: 5
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex |
| Component | GO:0020011 | apicoplast |
| Component | GO:0030176 | integral component of endoplasmic reticulum membrane |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0051787 | misfolded protein binding |
| Function | GO:1990381 | ubiquitin-specific protease binding |
| Process | GO:0030968 | endoplasmic reticulum unfolded protein response |
| Process | GO:0010564 | regulation of cell cycle process |
| Process | GO:0030433 | ubiquitin-dependent ERAD pathway |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | possibly expressed | 0.29 | 0.81 |
| Schizont | not expressed | 0.07 | 0.96 |
| Gametocyte | not expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1452300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.389 | MFS: -1.07 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1316000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1316000)
Modification: Disrupted | RMgm-3482
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKV3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 20 | 13 | 23 |
| disruptive | 5 | 32 | 23 | 52 |
| missense | 5 | 32 | 23 | 49 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 47 | 14 | 29 |
| disruptive | 12 | 77 | 43 | 68 |
| missense | 11 | 70 | 36 | 47 |
PlasmoDB Total SNPs: 69
Non-coding: 49 | Synonymous: 13 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 354 | Molecular Weight (kDa): 41.703
UniProt ID(s): Q8IKV3
PDB ID(s): None
Isoelectric Point: 10.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007599 | Derlin |
| PFam | PF04511 | Derlin |
| Superfamily | SSF144091 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 19502580 | Characterization of two putative protein translocation components in theapicoplast of Plasmodium falciparum. | Kalanon M, Tonkin CJ, McFadden GI | 10.1128/EC.00061-09 |
| 19502583 | An unusual ERAD-like complex is targeted to the apicoplast of Plasmodiumfalciparum. | Spork S, Hiss JA, ..., Przyborski JM | 10.1128/EC.00083-09 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |