About Gene List

PF3D7_1452400

Genome location: Pf3D7_14_v3:2,146,941..2,151,334(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.69 0.68
Trophozoite expressed 1.05 0.46
Schizont expressed 0.32 0.81
Gametocyte expressed 0.93 0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1452400

Resistome Missense Mutations: P870Q

Resistome Compounds with Missense Mutations: Atovaquone

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.502 | MFS: -2.536 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1316100)

  • Relative Growth Rate: 0.30 ± 0.20
  • Confidence: 4.65

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1316100)

Modification: Disrupted | RMgm-3483

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKV2

"Best" AlphaFill ligand hit: PAM (palmitoleic acid, Local RMSD=0.07) with 6C0B (Global RMSD=22.94)

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
P0C6X4 Replicase polyprotein 1ab OrthoMCL BLAST cmdc.202100576, 6bUS9975885, Compound 6US9975885, Compound 13US9975885, Compound 14...

Orthology Information

Ortholog Group (OrthoMCL): OG6_193862

No human ortholog(s)

Protein Information

Protein Length: 900 | Molecular Weight (kDa): 107.499

UniProt ID(s): Q8IKV2

PDB ID(s): None

Isoelectric Point: 4.99

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 38 19 43
disruptive 12 131 90 164
missense 11 122 85 136

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 78 34 48
disruptive 41 265 122 247
missense 32 227 96 175

PlasmoDB Total SNPs: 213

Non-coding: 75 | Synonymous: 76 | Nonsynonymous: 62 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108