Genome location: Pf3D7_14_v3:2,151,389..2,154,604(-)
Genome classification: Core
Product Description: syntaxin-6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031201 | SNARE complex |
| Component | GO:0012505 | endomembrane system |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005802 | trans-Golgi network |
| Function | GO:0005484 | SNAP receptor activity |
| Function | GO:0000149 | SNARE binding |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0048278 | vesicle docking |
| Process | GO:0006906 | vesicle fusion |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.17 | 0.89 |
| Schizont | expressed | 0.31 | 0.79 |
| Gametocyte | expressed | 0.37 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1452500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.128 | MFS: -3.041 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1316200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKV1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101619
Most Similar Human Ortholog: F6RTM7
TM-align score: 0.77 | RMSD: 2.12
Seq Identity: 0.07 | Length: 72 / 211
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104915 | syntaxin 10 |
| ENSG00000135823 | syntaxin 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 209
Non-coding: 197 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 211 | Molecular Weight (kDa): 24.7
PDB ID(s): None
Isoelectric Point: 4.77
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000727 | Target SNARE coiled-coil homology domain |
| InterPro | IPR010989 | SNARE |
| InterPro | IPR015260 | Syntaxin 6, N-terminal |
| PFam | PF09177 | Syntaxin 6, N-terminal |
| Superfamily | SSF47661 | SNARE |
| Superfamily | SSF58038 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23962112 | Toxoplasma gondii Syntaxin 6 is required for vesicular transport betweenendosomal-like compartments and the Golgi complex. | Jackson AJ, Clucas C, ..., Meissner M | 10.1111/tra.12102 |