PF3D7_1452600

Genome location: Pf3D7_14_v3:2,154,831..2,166,467(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.51	0.77
Trophozoite	expressed	1.07	0.48
Schizont	expressed	1.46	0.36
Gametocyte	possibly expressed	1.18	0.43

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1452600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -2.896 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1316300)

Modification: Disrupted | RMgm-3485

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532850

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	33	200	129	260
disruptive	100	554	298	715
missense	79	503	276	627

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	61	408	182	264
disruptive	227	1202	501	1051
missense	159	1033	423	766

PlasmoDB Total SNPs: 410

Non-coding: 105 | Synonymous: 189 | Nonsynonymous: 116 | Stop Codon: 0

Protein Information

Protein Length: 3347 | Molecular Weight (kDa): 399.999

UniProt ID(s): Q8IKV0

PDB ID(s): None

Isoelectric Point: 6.65

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010301	Nucleolar, Nop52
InterPro	IPR032629	Mon2, dimerisation and cyclophilin-binding domain
PFam	PF16213	Mon2, dimerisation and cyclophilin-binding domain
Superfamily	N/A	N/A