PF3D7_1452700

Genome location: Pf3D7_14_v3:2,167,219..2,169,997(+)

Genome classification: Core

Function and Localization

Product Description: U1 snRNP-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005685	U1 snRNP
Component	GO:0071004	U2-type prespliceosome
Function	GO:0003729	mRNA binding
Process	GO:0006376	mRNA splice site selection

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.95
Trophozoite	expressed	0.69	0.62
Schizont	expressed	0.16	0.90
Gametocyte	expressed	0.62	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1452700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.191 | MFS: -3.134 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKU9

"Best" AlphaFill ligand hit: FMN (flavin mononucleotide, Local RMSD=4.03) with 7TAL (Global RMSD=24.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103742

Most Similar Human Ortholog: D6RHH0

TM-align score: 0.80 | RMSD: 1.11

Seq Identity: 0.08 | Length: 36 / 336

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000108848	LUC7 like 3 pre-mRNA splicing factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	21	9	30
disruptive	6	34	23	48
missense	6	33	22	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	46	17	32
disruptive	9	100	45	115
missense	8	93	38	66

PlasmoDB Total SNPs: 137

Non-coding: 125 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 336 | Molecular Weight (kDa): 40.185

UniProt ID(s): Q8IKU9

PDB ID(s): None

Isoelectric Point: 10.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004882	Luc7-related
PFam	PF03194	Luc7-related
Superfamily	N/A	N/A