PF3D7_1452800

Genome location: Pf3D7_14_v3:2,170,012..2,171,844(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.04	0.97
Schizont	not expressed	0.02	0.98
Gametocyte	not expressed	0.33	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1452800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.825 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKU8

"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=1.83) with 3IED (Global RMSD=45.37)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_116079

Most Similar Human Ortholog: Q9BXX0

TM-align score: 0.45 | RMSD: 3.82

Seq Identity: 0.06 | Length: 145 / 256

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000132205	elastin microfibril interfacer 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	15	13	22
disruptive	8	39	31	55
missense	8	39	31	53

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	29	18	19
disruptive	15	86	38	68
missense	15	74	35	65

PlasmoDB Total SNPs: 112

Non-coding: 89 | Synonymous: 16 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 256 | Molecular Weight (kDa): 30.838

UniProt ID(s): Q8IKU8

PDB ID(s): None

Isoelectric Point: 5.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A