About Gene List

PF3D7_1452900

Genome location: Pf3D7_14_v3:2,171,480..2,172,584(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite possibly expressed 0.28 0.82
Schizont possibly expressed 0.14 0.90
Gametocyte possibly expressed 0.80 0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1452900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.077 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3J3

"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.24) with 2OK7 (Global RMSD=20.32)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146153

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 13 6 14
disruptive 4 24 18 38
missense 4 24 18 34

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 24 8 16
disruptive 14 67 29 63
missense 11 57 28 51

PlasmoDB Total SNPs: 19

Non-coding: 5 | Synonymous: 10 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 228 | Molecular Weight (kDa): 27.939

UniProt ID(s): C6S3J3

PDB ID(s): None

Isoelectric Point: 10.43

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094