PF3D7_1453000

Genome location: Pf3D7_14_v3:2,173,011..2,176,425(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.49	0.77
Trophozoite	possibly expressed	0.67	0.62
Schizont	possibly expressed	0.21	0.87
Gametocyte	possibly expressed	0.36	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1453000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.921 | MFS: -2.955 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1316700)

Relative Growth Rate: 0.60 ± 0.12
Confidence: 5.64

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1316700)

Modification: Disrupted | RMgm-3486

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKU7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533238

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	38	44	51
disruptive	23	170	108	212
missense	17	163	105	198

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	102	35	60
disruptive	56	368	139	317
missense	42	319	124	255

PlasmoDB Total SNPs: 88

Non-coding: 20 | Synonymous: 39 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 931 | Molecular Weight (kDa): 110.617

UniProt ID(s): Q8IKU7

PDB ID(s): None

Isoelectric Point: 4.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094