PF3D7_1453100

Genome location: Pf3D7_14_v3:2,176,837..2,178,729(-)

Genome classification: Core

Function and Localization

Product Description: dynactin subunit 4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005869	dynactin complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.19	0.89
Schizont	not expressed	0.30	0.81
Gametocyte	not expressed	0.69	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1453100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.994 | MFS: -1.81 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKU6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533007

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	31	18	49
disruptive	10	89	47	110
missense	10	84	47	108

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	70	31	52
disruptive	30	169	78	172
missense	22	157	69	147

PlasmoDB Total SNPs: 53

Non-coding: 0 | Synonymous: 32 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 630 | Molecular Weight (kDa): 75.144

UniProt ID(s): Q8IKU6

PDB ID(s): None

Isoelectric Point: 7.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008603	Dynactin subunit 4
PFam	N/A	N/A
Superfamily	N/A	N/A