PF3D7_1453200

Genome location: Pf3D7_14_v3:2,179,447..2,186,667(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.46	0.75
Schizont	expressed	0.74	0.61
Gametocyte	possibly expressed	0.39	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1453200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.704 | MFS: -1.834 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1316900)

Relative Growth Rate: 0.69 ± 0.15
Confidence: 5.21

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1316900)

Modification: Disrupted | RMgm-3487

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKU5

"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=0.09) with 7DI7 (Global RMSD=23.27)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532908

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	57	44	100
disruptive	35	111	91	231
missense	35	109	89	219

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	118	71	117
disruptive	57	317	144	370
missense	46	279	131	288

PlasmoDB Total SNPs: 327

Non-coding: 251 | Synonymous: 40 | Nonsynonymous: 36 | Stop Codon: 0

Protein Information

Protein Length: 1495 | Molecular Weight (kDa): 178.342

UniProt ID(s): Q8IKU5

PDB ID(s): None

Isoelectric Point: 8.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52047	N/A