Product Description: Yos1-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.01 | 1.00 |
| Trophozoite | no data | 0.01 | 0.99 |
| Schizont | no data | 0.00 | 1.00 |
| Gametocyte | no data | 0.01 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1453300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.228 | MFS: -3.556 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3J4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103811
Most Similar Human Ortholog: R4GN61
TM-align score: 0.73 | RMSD: 0.98
Seq Identity: 0.09 | Length: 34 / 76
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134049 | immediate early response 3 interacting protein 1 |
| ENSG00000267228 | novel transcript |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 3 | 1 | 7 |
| disruptive | 0 | 3 | 2 | 6 |
| missense | 0 | 3 | 2 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 0 | 6 |
| disruptive | 1 | 9 | 5 | 16 |
| missense | 0 | 6 | 5 | 10 |
PlasmoDB Total SNPs: 1
Non-coding: 0 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 76 | Molecular Weight (kDa): 9.053
UniProt ID(s): C6S3J4
PDB ID(s): None
Isoelectric Point: 9.48
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013880 | Yos1-like |
| PFam | PF08571 | Yos1-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |