PF3D7_1453400

Genome location: Pf3D7_14_v3:2,188,118..2,194,487(+)

Genome classification: Core

Function and Localization

Product Description: gamma-tubulin complex component, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005813	centrosome
Component	GO:0000923	equatorial microtubule organizing center
Component	GO:0000930	gamma-tubulin complex
Component	GO:0008275	gamma-tubulin small complex
Function	GO:0043015	gamma-tubulin binding
Process	GO:0031122	cytoplasmic microtubule organization
Process	GO:0051321	meiotic cell cycle
Process	GO:0051415	microtubule nucleation by interphase microtubule organizing center
Process	GO:0000278	mitotic cell cycle
Process	GO:0051225	spindle assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.62	0.72
Trophozoite	possibly expressed	0.97	0.50
Schizont	possibly expressed	0.57	0.68
Gametocyte	possibly expressed	0.97	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1453400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.893 | #Insertions: 12

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKU4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533685

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	103	49	126
disruptive	28	236	163	367
missense	21	223	152	342

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	194	71	152
disruptive	81	501	285	498
missense	52	451	248	391

PlasmoDB Total SNPs: 185

Non-coding: 65 | Synonymous: 81 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1923 | Molecular Weight (kDa): 233.301

UniProt ID(s): Q8IKU4

PDB ID(s): None

Isoelectric Point: 7.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007259	Gamma-tubulin complex component protein
PFam	N/A	N/A
Superfamily	N/A	N/A