PF3D7_1453600

Genome location: Pf3D7_14_v3:2,199,258..2,205,138(-)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.15	0.92
Trophozoite	expressed	0.35	0.81
Schizont	possibly expressed	0.06	0.96
Gametocyte	possibly expressed	0.47	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1453600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.673 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKU2

"Best" AlphaFill ligand hit: LFA (lipid fragment, Local RMSD=0.02) with 4XTL (Global RMSD=17.67)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532611

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	88	68	111
disruptive	70	308	164	387
missense	50	283	150	350

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	179	67	127
disruptive	128	604	263	480
missense	88	533	236	368

PlasmoDB Total SNPs: 235

Non-coding: 76 | Synonymous: 90 | Nonsynonymous: 69 | Stop Codon: 0

Protein Information

Protein Length: 1725 | Molecular Weight (kDa): 208.227

UniProt ID(s): Q8IKU2

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	N/A	N/A