Genome location: Pf3D7_14_v3:2,206,046..2,209,273(+)
Genome classification: Core
Product Description: HSP90 co-chaperone p23
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0051879 | Hsp90 protein binding |
| Function | GO:0051087 | chaperone binding |
| Process | GO:0051131 | chaperone-mediated protein complex assembly |
| Process | GO:0032780 | negative regulation of ATP-dependent activity |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.99 | 0.24 |
| Trophozoite | expressed | 2.52 | 0.12 |
| Schizont | expressed | 0.53 | 0.71 |
| Gametocyte | expressed | 1.97 | 0.19 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1453700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.682 | MFS: -3.002 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKU1
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.70) with 2IF8 (Global RMSD=13.20)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101574
Most Similar Human Ortholog: A0A087WYT3
TM-align score: 0.72 | RMSD: 3.13
Seq Identity: 0.19 | Length: 144 / 275
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000110958 | prostaglandin E synthase 3 |
| ENSG00000267060 | prostaglandin E synthase 3 like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 149
Non-coding: 135 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 275 | Molecular Weight (kDa): 30.492
PDB ID(s): None
Isoelectric Point: 3.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007052 | CS domain |
| InterPro | IPR008978 | HSP20-like chaperone |
| PFam | PF04969 | CS domain |
| Superfamily | SSF49764 | HSP20-like chaperone |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12756555 | A Plasmodium homologue of cochaperone p23 and its differential expression duringthe replicative cycle of the malaria parasite. | Wiser MF | 10.1007/s00436-003-0835-4 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 20140477 | Characterization of Plasmodium falciparum co-chaperone p23: its intrinsicchaperone activity and interaction with Hsp90. | Chua CS, Low H, Goo KS, Sim TS | 10.1007/s00018-010-0275-0 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 29191421 | Comparative studies of the low-resolution structure of two p23 co-chaperones forHsp90 identified in Plasmodium falciparum genome. | Silva NSM, Seraphim TV, ..., Borges JC | 10.1016/j.ijbiomac.2017.11.161 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |