PF3D7_1453900

Genome location: Pf3D7_14_v3:2,213,606..2,218,299(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.67	0.68
Trophozoite	possibly expressed	0.36	0.79
Schizont	not expressed	0.23	0.85
Gametocyte	not expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1453900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -2.752 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKT9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532985

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	54	38	60
disruptive	51	220	95	250
missense	33	186	80	214

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	98	51	64
disruptive	86	443	189	286
missense	61	360	162	194

PlasmoDB Total SNPs: 188

Non-coding: 89 | Synonymous: 44 | Nonsynonymous: 55 | Stop Codon: 0

Protein Information

Protein Length: 961 | Molecular Weight (kDa): 111.445

UniProt ID(s): Q8IKT9

PDB ID(s): None

Isoelectric Point: 4.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A