PF3D7_1454000

Genome location: Pf3D7_14_v3:2,218,537..2,220,914(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003723	RNA binding
Process	GO:0006281	DNA repair
Process	GO:0000380	alternative mRNA splicing, via spliceosome
Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.40	0.81
Trophozoite	expressed	0.56	0.69
Schizont	possibly expressed	0.09	0.94
Gametocyte	possibly expressed	0.45	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1454000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.244 | MFS: -2.624 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKT8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103640

Most Similar Human Ortholog: Q96I25

TM-align score: 0.34 | RMSD: 6.20

Seq Identity: 0.20 | Length: 195 / 511

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000134453	RNA binding motif protein 17

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	27	20	49
disruptive	5	60	52	127
missense	5	59	50	123

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	60	25	42
disruptive	19	174	73	162
missense	14	153	69	121

PlasmoDB Total SNPs: 56

Non-coding: 36 | Synonymous: 9 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 511 | Molecular Weight (kDa): 59.423

UniProt ID(s): Q8IKT8

PDB ID(s): None

Isoelectric Point: 5.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000467	G-patch domain
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR003954	RNA recognition motif domain, eukaryote
InterPro	IPR035979	RNA-binding domain superfamily
InterPro	IPR040052	Splicing factor 45
PFam	PF00076	RNA recognition motif domain
PFam	PF01585	G-patch domain
Superfamily	SSF54928	RNA-binding domain superfamily