Product Description: tRNA intron endonuclease, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.27.9 (Transferred entry: 4.6.1.16);4.6.1.16 (tRNA-intron lyase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0000214 | tRNA-intron endonuclease complex |
| Function | GO:0000213 | tRNA-intron endonuclease activity |
| Process | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.14 | 0.90 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | not expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1454100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.125 | MFS: -3.121 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I718
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102602
Most Similar Human Ortholog: A0A590UJ73
TM-align score: 0.85 | RMSD: 1.87
Seq Identity: 0.16 | Length: 96 / 97
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000170892 | tRNA splicing endonuclease subunit 34 |
| ENSG00000273896 | tRNA splicing endonuclease subunit 34 |
| ENSG00000274078 | tRNA splicing endonuclease subunit 34 |
| ENSG00000274129 | tRNA splicing endonuclease subunit 34 |
| ENSG00000274672 | tRNA splicing endonuclease subunit 34 |
| ENSG00000274796 | tRNA splicing endonuclease subunit 34 |
| ENSG00000275165 | tRNA splicing endonuclease subunit 34 |
| ENSG00000278605 | tRNA splicing endonuclease subunit 34 |
| ENSG00000278622 | tRNA splicing endonuclease subunit 34 |
| ENSG00000278712 | tRNA splicing endonuclease subunit 34 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 35
Non-coding: 33 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 97 | Molecular Weight (kDa): 11.64
UniProt ID(s): Q8I718
PDB ID(s): None
Isoelectric Point: 9.41
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006677 | tRNA intron endonuclease, catalytic domain-like |
| InterPro | IPR036167 | tRNA intron endonuclease, catalytic domain-like superfamily |
| PFam | PF01974 | tRNA intron endonuclease, catalytic domain-like |
| Superfamily | SSF53032 | tRNA intron endonuclease, catalytic domain-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |