About Gene List

PF3D7_1454200

Genome location: Pf3D7_14_v3:2,222,463..2,227,264(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Process GO:0006351 transcription, DNA-templated

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.96 0.57
Trophozoite not expressed 0.52 0.72
Schizont not expressed 0.13 0.92
Gametocyte not expressed 0.54 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1454200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.633 | MFS: 0.08 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKT7

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=11.91) with 4DKJ (Global RMSD=15.62)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532354

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 70 38 86
disruptive 31 156 83 250
missense 20 134 76 219

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 135 72 113
disruptive 70 338 186 355
missense 39 281 149 267

PlasmoDB Total SNPs: 100

Non-coding: 16 | Synonymous: 53 | Nonsynonymous: 31 | Stop Codon: 0

Protein Information

Protein Length: 1404 | Molecular Weight (kDa): 168.933

UniProt ID(s): Q8IKT7

PDB ID(s): None

Isoelectric Point: 9.51

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31390575 Landscape of the Plasmodium Interactome Reveals Both Conserved andSpecies-Specific Functionality. Hillier C, Pardo M, ..., Choudhary JS 10.1016/j.celrep.2019.07.019