About Gene List

PF3D7_1454600

Genome location: Pf3D7_14_v3:2,239,017..2,240,274(-)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S11, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005763 mitochondrial small ribosomal subunit
Component GO:0005739 mitochondrion
Component GO:0000314 organellar small ribosomal subunit
Function GO:0048027 mRNA 5'-UTR binding
Function GO:0070181 small ribosomal subunit rRNA binding
Function GO:0003735 structural constituent of ribosome
Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Process GO:0000028 ribosomal small subunit assembly
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.06 0.97
Trophozoite expressed 0.20 0.87
Schizont expressed 0.05 0.96
Gametocyte expressed 0.14 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1454600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.347 | MFS: -2.911 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1318300)

  • Relative Growth Rate: 0.07 ± 0.04
  • Confidence: 7.60

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKT3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134443

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 13 9 24
disruptive 0 11 6 25
missense 0 11 6 23

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 39 10 16
disruptive 2 29 11 47
missense 2 25 11 31

PlasmoDB Total SNPs: 43

Non-coding: 37 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 229 | Molecular Weight (kDa): 26.528

UniProt ID(s): Q8IKT3

PDB ID(s): None

Isoelectric Point: 11.03

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001971 Ribosomal protein S11
PFam N/A N/A
Superfamily SSF53137 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21