PF3D7_1454800

Genome location: Pf3D7_14_v3:2,243,873..2,244,367(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.12	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1454800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.473 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1322300)

Modification: Disrupted | RMgm-5289

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKT1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532901

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	7	12
disruptive	2	14	9	30
missense	2	14	9	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	14	12	14
disruptive	6	30	12	47
missense	6	29	12	37

PlasmoDB Total SNPs: 10

Non-coding: 0 | Synonymous: 5 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 164 | Molecular Weight (kDa): 19.387

UniProt ID(s): Q8IKT1

PDB ID(s): None

Isoelectric Point: 5.48

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A