PF3D7_1454900

Genome location: Pf3D7_14_v3:2,244,961..2,245,795(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.00	1.00
Trophozoite	expressed	0.00	1.00
Schizont	expressed	0.00	1.00
Gametocyte	expressed	0.67	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1454900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.647 | MFS: -2.439 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1322400)

Modification: Disrupted | RMgm-5288

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKT0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109961

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	8	11
disruptive	2	6	3	10
missense	2	6	2	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	18	10	17
disruptive	2	17	6	32
missense	2	13	5	23

PlasmoDB Total SNPs: 31

Non-coding: 26 | Synonymous: 1 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 154 | Molecular Weight (kDa): 17.377

UniProt ID(s): Q8IKT0

PDB ID(s): None

Isoelectric Point: 6.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A