PF3D7_1455000 (PPM3)

Genome location: Pf3D7_14_v3:2,246,812..2,250,659(-)

Genome classification: Core

Function and Localization

Product Description: protein phosphatase PPM3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1455000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.574 | MFS: -3.109 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1318700)

• Relative Growth Rate: 1.01 ± 0.18
• Confidence: 4.77

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1318700)

Modification: Disrupted | RMgm-3495

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKS9

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

Orthology to BindingDB Entries:

Orthology Information

Ortholog Group (OrthoMCL): OG6_151627

No human ortholog(s)

Protein Information

Protein Length: 410 | Molecular Weight (kDa): 47.477

UniProt ID(s): Q8IKS9

PDB ID(s): None

Isoelectric Point: 7.69

Protein Domain Annotations:

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 172

Non-coding: 157 | Synonymous: 15 | Nonsynonymous: 0 | Stop Codon: 0