Genome location: Pf3D7_14_v3:2,262,633..2,264,484(-)
Genome classification: Core
Product Description: hemolysin III
SignalP Peptide: N/A
# Transmembrane Domains: 7
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020020 | food vacuole |
| Component | GO:0016020 | membrane |
| Function | GO:0038023 | signaling receptor activity |
| Process | GO:0044179 | hemolysis in other organism |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.18 | 0.91 |
| Trophozoite | possibly expressed | 0.21 | 0.86 |
| Schizont | not expressed | 0.04 | 0.97 |
| Gametocyte | not expressed | 0.12 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1455400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.149 | MFS: -2.758 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1319100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1319100)
Modification: Disrupted | RMgm-3497
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKS4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100486
Most Similar Human Ortholog: Q96A54
TM-align score: 0.71 | RMSD: 2.35
Seq Identity: 0.18 | Length: 221 / 282
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000006831 | adiponectin receptor 2 |
| ENSG00000159346 | adiponectin receptor 1 |
| ENSG00000285070 | adiponectin receptor 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 21 | 3 | 29 |
| disruptive | 7 | 12 | 8 | 22 |
| missense | 7 | 12 | 8 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 31 | 15 | 32 |
| disruptive | 12 | 32 | 27 | 81 |
| missense | 10 | 25 | 20 | 51 |
PlasmoDB Total SNPs: 128
Non-coding: 104 | Synonymous: 16 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 282 | Molecular Weight (kDa): 33.072
UniProt ID(s): Q8IKS4
PDB ID(s): None
Isoelectric Point: 9.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004254 | AdipoR/Haemolysin-III-related |
| PFam | PF03006 | AdipoR/Haemolysin-III-related |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25148832 | Erythrocyte lysis and Xenopus laevis oocyte rupture by recombinant Plasmodiumfalciparum hemolysin III. | Moonah S, Sanders NG, Persichetti JK, Sullivan DJ Jr | 10.1128/EC.00088-14 |