Product Description: AP-1 complex subunit gamma, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030121 | AP-1 adaptor complex |
| Component | GO:0030131 | clathrin adaptor complex |
| Component | GO:0005634 | nucleus |
| Component | GO:0005802 | trans-Golgi network |
| Function | GO:0140312 | cargo adaptor activity |
| Function | GO:0035615 | clathrin adaptor activity |
| Process | GO:0006896 | Golgi to vacuole transport |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0006898 | receptor-mediated endocytosis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.29 | 0.86 |
| Trophozoite | not expressed | 0.55 | 0.67 |
| Schizont | possibly expressed | 0.28 | 0.82 |
| Gametocyte | not expressed | 0.46 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1455500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.152 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1319200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKS3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101228
Most Similar Human Ortholog: H3BR36
TM-align score: 0.96 | RMSD: 0.90
Seq Identity: 0.56 | Length: 185 / 1081
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000166747 | adaptor related protein complex 1 subunit gamma 1 |
| ENSG00000213983 | adaptor related protein complex 1 subunit gamma 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 58 | 29 | 81 |
| disruptive | 19 | 100 | 61 | 164 |
| missense | 14 | 85 | 54 | 130 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 127 | 54 | 77 |
| disruptive | 45 | 242 | 138 | 288 |
| missense | 27 | 182 | 106 | 176 |
PlasmoDB Total SNPs: 169
Non-coding: 83 | Synonymous: 57 | Nonsynonymous: 29 | Stop Codon: 0
Protein Length: 1081 | Molecular Weight (kDa): 124.243
UniProt ID(s): Q8IKS3
PDB ID(s): None
Isoelectric Point: 6.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| InterPro | IPR008152 | Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain |
| InterPro | IPR013041 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR017104 | Adaptor protein complex AP-2, alpha subunit |
| PFam | PF01602 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| PFam | PF02883 | Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain |
| Superfamily | SSF48371 | Armadillo-type fold |
| Superfamily | SSF49348 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |