Genome location: Pf3D7_14_v3:2,271,364..2,277,727(-)
Genome classification: Core
Product Description: ferlin, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Process | GO:0007009 | plasma membrane organization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | not expressed | 0.09 | 0.95 |
| Schizont | expressed | 0.56 | 0.69 |
| Gametocyte | not expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1455600
Resistome Missense Mutations: T1710I
Resistome Compounds with Missense Mutations: Atovaquone
Resistome # Samples with Disruptive Mutations: 5 (2 missense, 2 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.131 | MFS: -2.971 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1319300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKS2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 91 | 53 | 128 |
| disruptive | 45 | 137 | 89 | 213 |
| missense | 29 | 113 | 81 | 178 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 32 | 199 | 85 | 135 |
| disruptive | 82 | 272 | 155 | 400 |
| missense | 45 | 224 | 131 | 302 |
PlasmoDB Total SNPs: 184
Non-coding: 43 | Synonymous: 90 | Nonsynonymous: 49 | Stop Codon: 2
Protein Length: 1904 | Molecular Weight (kDa): 224.721
UniProt ID(s): Q8IKS2
PDB ID(s): None
Isoelectric Point: 8.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000008 | C2 domain |
| InterPro | IPR037721 | Ferlin family |
| PFam | PF00168 | C2 domain |
| Superfamily | SSF49562 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 30279285 | A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondiiRhoptry Secretion | Coleman BI, Saha S, ..., Gubbels MJ | 10.1128/mBio.01510-18 |
| 33803212 | Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion | Tagoe DNA, Drozda AA, ..., Gubbels MJ | 10.3390/life11030217 |