Genome location: Pf3D7_14_v3:2,296,438..2,301,291(+)
Genome classification: Core
Product Description: AP2 domain transcription factor AP2-HC
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000792 | heterochromatin |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Function | GO:0043565 | sequence-specific DNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.97 | 0.51 |
| Schizont | expressed | 0.73 | 0.62 |
| Gametocyte | not expressed | 0.67 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1456000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.382 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1323500)
Modification: Disrupted | RMgm-4392
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKR9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P01042 | Kininogen-1 | Homo sapiens | OrthoMCL BLAST | US8592426, 1US8592426, 2US8592426, 3US8592426, 4... |
Protein Length: 1374 | Molecular Weight (kDa): 161.509
UniProt ID(s): Q8IKR9
PDB ID(s): None
Isoelectric Point: 9.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001471 | AP2/ERF domain |
| PFam | PF00847 | AP2/ERF domain |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 63 | 33 | 84 |
| disruptive | 41 | 200 | 104 | 254 |
| missense | 25 | 163 | 90 | 208 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 137 | 55 | 87 |
| disruptive | 104 | 438 | 227 | 437 |
| missense | 56 | 329 | 156 | 264 |
PlasmoDB Total SNPs: 286
Non-coding: 65 | Synonymous: 133 | Nonsynonymous: 88 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21060817 | Identification and genome-wide prediction of DNA binding specificities for theApiAP2 family of regulators from the malaria parasite. | Campbell TL, De Silva EK, ..., Llinas M | 10.1371/journal.ppat.1001165 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 33997710 | The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in themalaria parasite Plasmodium falciparum. | Carrington E, Cooijmans RHM, ..., Voss TS | 10.1016/j.isci.2021.102444 |
| 35288749 | Genome-wide landscape of ApiAP2 transcription factors reveals aheterochromatin-associated regulatory network during Plasmodium falciparumblood-stage development. | Shang X, Wang C, ..., Zhang Q | 10.1093/nar/gkac176 |