About Gene List

PF3D7_1456300

Genome location: Pf3D7_14_v3:2,306,546..2,308,637(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.16 0.92
Trophozoite expressed 0.24 0.87
Schizont possibly expressed 0.03 0.98
Gametocyte not expressed 0.28 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1456300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -2.975 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKR6

"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=1.31) with 4USS (Global RMSD=18.98)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532564

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 26 8 32
disruptive 7 45 36 87
missense 4 43 35 82

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 45 20 27
disruptive 22 125 54 133
missense 14 108 41 96

PlasmoDB Total SNPs: 42

Non-coding: 21 | Synonymous: 17 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 415 | Molecular Weight (kDa): 50.459

UniProt ID(s): Q8IKR6

PDB ID(s): None

Isoelectric Point: 9.44

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094