Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | possibly expressed | 0.16 | 0.92 |
Trophozoite | expressed | 0.24 | 0.87 |
Schizont | possibly expressed | 0.03 | 0.98 |
Gametocyte | not expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1456300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.124 | MFS: -2.975 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKR6
"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=1.31) with 4USS (Global RMSD=18.98)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 26 | 8 | 32 |
disruptive | 7 | 45 | 36 | 87 |
missense | 4 | 43 | 35 | 82 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 7 | 45 | 20 | 27 |
disruptive | 22 | 125 | 54 | 133 |
missense | 14 | 108 | 41 | 96 |
PlasmoDB Total SNPs: 42
Non-coding: 21 | Synonymous: 17 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 415 | Molecular Weight (kDa): 50.459
UniProt ID(s): Q8IKR6
PDB ID(s): None
Isoelectric Point: 9.44
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |