About Gene List

PF3D7_1456500

Genome location: Pf3D7_14_v3:2,313,655..2,321,652(+)

Genome classification: Core

Function and Localization

Product Description: STAG domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0008278 cohesin complex
Component GO:0005634 nucleus
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.18 0.92
Trophozoite expressed 1.42 0.37
Schizont expressed 0.62 0.69
Gametocyte expressed 1.56 0.30

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1456500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.035 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKR4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533538

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 19 94 83 166
disruptive 59 286 200 377
missense 39 262 182 349

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 33 232 111 190
disruptive 106 663 297 602
missense 67 570 249 448

PlasmoDB Total SNPs: 281

Non-coding: 63 | Synonymous: 124 | Nonsynonymous: 93 | Stop Codon: 1

Protein Information

Protein Length: 2391 | Molecular Weight (kDa): 283.202

UniProt ID(s): Q8IKR4

PDB ID(s): None

Isoelectric Point: 7.22

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013721 STAG
PFam PF08514 STAG
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108