PF3D7_1456700

Genome location: Pf3D7_14_v3:2,323,609..2,327,134(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.28	0.86
Trophozoite	expressed	0.58	0.66
Schizont	expressed	0.29	0.81
Gametocyte	expressed	0.63	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1456700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.01 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1320400)

Relative Growth Rate: 0.29 ± 0.41
Confidence: 3.16

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKR2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146162

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	37	17	59
disruptive	4	34	15	54
missense	1	29	10	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	86	29	58
disruptive	14	106	56	160
missense	8	69	37	100

PlasmoDB Total SNPs: 147

Non-coding: 103 | Synonymous: 39 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 684 | Molecular Weight (kDa): 77.81

UniProt ID(s): Q8IKR2

PDB ID(s): None

Isoelectric Point: 4.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104