PF3D7_1456900

Genome location: Pf3D7_14_v3:2,333,152..2,336,259(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.05	0.97
Trophozoite	possibly expressed	0.09	0.94
Schizont	expressed	0.01	0.99
Gametocyte	not expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1456900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.554 | MFS: 0 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKR0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102805

Most Similar Human Ortholog: Q8WUR7

TM-align score: 0.62 | RMSD: 1.86

Seq Identity: 0.23 | Length: 100 / 147

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000169609	chromosome 15 open reading frame 40

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	7	5	9
disruptive	3	16	6	28
missense	3	16	5	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	15	11	11
disruptive	7	41	17	48
missense	4	34	16	31

PlasmoDB Total SNPs: 124

Non-coding: 116 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 147 | Molecular Weight (kDa): 16.915

UniProt ID(s): Q8IKR0

PDB ID(s): None

Isoelectric Point: 10.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003746	Protein of unknown function DUF167
InterPro	IPR036591	YggU-like superfamily
PFam	PF02594	Protein of unknown function DUF167
Superfamily	SSF69786	YggU-like superfamily