PF3D7_1457100

Genome location: Pf3D7_14_v3:2,339,830..2,343,206(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.10	0.95
Trophozoite	expressed	0.19	0.88
Schizont	expressed	0.16	0.89
Gametocyte	expressed	0.71	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1457100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.534 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKQ8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532778

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	39	20	42
disruptive	27	163	94	197
missense	26	160	94	184

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	60	30	55
disruptive	54	320	130	284
missense	51	303	117	193

PlasmoDB Total SNPs: 193

Non-coding: 105 | Synonymous: 50 | Nonsynonymous: 38 | Stop Codon: 0

Protein Information

Protein Length: 747 | Molecular Weight (kDa): 88.798

UniProt ID(s): Q8IKQ8

PDB ID(s): None

Isoelectric Point: 6.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A