Genome location: Pf3D7_14_v3:2,343,508..2,344,657(-)
Genome classification: Core
Product Description: thioredoxin 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.13 | 0.94 |
| Trophozoite | expressed | 0.77 | 0.58 |
| Schizont | expressed | 0.50 | 0.71 |
| Gametocyte | expressed | 0.31 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1457200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.156 | MFS: -2.728 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1320900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1320900)
Modification: Disrupted | RMgm-3508
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7KQL8
"Best" AlphaFill ligand hit: DTU ((2r,3s)-1,4-dimercaptobutane-2,3-diol, Local RMSD=0.19) with 3ZZX (Global RMSD=1.16)
No associated EC numbersOrthology to BindingDB Entries:
Ortholog Group (OrthoMCL): OG6_100096
Most Similar Human Ortholog: P10599
TM-align score: 0.97 | RMSD: 0.61
Seq Identity: 0.39 | Length: 103 / 104
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000091164 | thioredoxin like 1 |
| ENSG00000100348 | thioredoxin 2 |
| ENSG00000136810 | thioredoxin |
Protein Length: 104 | Molecular Weight (kDa): 11.716
UniProt ID(s): A0A144A4E0, Q7KQL8, Q9NFK9, Q9NIR2
PDB ID(s): 1SYR, 2MMN, 2MMO, 4J56, 4J57
Isoelectric Point: 4.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005746 | Thioredoxin |
| InterPro | IPR013766 | Thioredoxin domain |
| InterPro | IPR017937 | Thioredoxin, conserved site |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF00085 | Thioredoxin domain |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 1 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 1 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 37
Non-coding: 32 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 20307687 | Target proteins of the cytosolic thioredoxin in Plasmodium falciparum. | Kawazu S, Takemae H, Komaki-Yasuda K, Kano S | 10.1016/j.parint.2010.03.005 |
| 21203490 | Compartmentation of redox metabolism in malaria parasites. | Kehr S, Sturm N, ..., Becker K | 10.1371/journal.ppat.1001242 |
| 38104697 | Effects of dietary chitosan oligosaccharide on the growth, intestinal microbiotaand immunity of juvenile red claw crayfish (Cherax quadricarinatus) | Zhang ZL, Cao YL, ..., Lu YP | 10.1016/j.fsi.2023.109288 |