Product Description: MA3 domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005634 | nucleus |
| Function | GO:0031369 | translation initiation factor binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.21 | 0.48 |
| Trophozoite | expressed | 1.13 | 0.44 |
| Schizont | expressed | 0.27 | 0.84 |
| Gametocyte | expressed | 0.42 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1457300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.046 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1321000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1321000)
Modification: Disrupted | RMgm-3509
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKQ7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q53EL6 | Programmed cell death protein 4 | Homo sapiens | OrthoDB, OrthoMCL BLAST | Cryptocaryol ACryptocaryol BCryptocaryol CCryptocaryol D... |
Ortholog Group (OrthoMCL): OG6_103300
Most Similar Human Ortholog: Q5VZS7
TM-align score: 0.40 | RMSD: 4.18
Seq Identity: 0.12 | Length: 121 / 639
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000150593 | programmed cell death 4 |
Protein Length: 639 | Molecular Weight (kDa): 75.987
UniProt ID(s): Q8IKQ7
PDB ID(s): None
Isoelectric Point: 4.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003891 | Initiation factor eIF-4 gamma, MA3 |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR039778 | Programmed cell death protein 4 |
| PFam | PF02847 | Initiation factor eIF-4 gamma, MA3 |
| Superfamily | SSF48371 | Armadillo-type fold |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 31 | 14 | 43 |
| disruptive | 12 | 61 | 34 | 79 |
| missense | 10 | 58 | 33 | 70 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 75 | 18 | 49 |
| disruptive | 29 | 129 | 63 | 171 |
| missense | 24 | 106 | 53 | 115 |
PlasmoDB Total SNPs: 225
Non-coding: 190 | Synonymous: 23 | Nonsynonymous: 12 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31390575 | Landscape of the Plasmodium Interactome Reveals Both Conserved andSpecies-Specific Functionality. | Hillier C, Pardo M, ..., Choudhary JS | 10.1016/j.celrep.2019.07.019 |